31. Various stress-induced elevations of ACTH are blunted in the Avpr1b knockout mouse. 32. ACTH receptor is primarily found in the zona fasciculata of the human adrenal cortex.33. Aldosterone synthase normally is not ACTH sensitive, and only activated by angiotensin II. 34. Reducing ACTH synthesis, it improves the sexual drive of rats under stressing conditions. 35. ACTH is also produced by corticotropes in the pars distalis of the equine pituitary.36. There are few alternative treatments and none are as effective as ACTH , experts say. 37. Conversely, chronically elevated ACTH levels occur in primary adrenal insufficiency ( e . g. 38. In turn, ACTH directs the adrenal cortex to secrete glucocorticoids, such as cortisol. 39. The ACTH receptor plays a role in glucose metabolism when expressed in white adipose cells. 40. ACTH receptor activation also influences immune function.
