31. Refractory Hypertension associated with autoantibodies to beta1-adrenergic receptors has been documented in diabetic patients. 32. This pathway can be initiated by adrenaline activating ?-adrenergic receptors on the cell surface. 33. Autoantibodies to beta1-adrenergic receptors are linked to chronic heart failure. 34. It works mainly by increasing the activity of norepinephrine ( noradrenaline ) on adrenergic receptors . 35. Pseudoephedrine acts indirectly on the adrenergic receptor system, whereas phenylephrine and oxymetazoline are direct agonists. 36. Epinephrine is a nonselective agonist of all adrenergic receptors , including the major subtypes ? 3. 37. Circulating autoantibodies to adrenergic receptors have been identified in numerous heart diseases and cardiac symptoms. 38. So cells with defective beta 3 adrenergic receptors might, in theory, burn calories too slowly. 39. Usually, the third residue from the C terminal is channels or the ? 2-adrenergic receptors . 40. Dihydroergotamine is more selective to ?-adrenergic receptors and has a weaker effect on serotonin receptors.