31. This suggests a possible cause for the elevated frequency of abnormal chromosome counts ( aneuploidy ) in mammals. 32. In 2007, " Scientific American " published an article by Duesberg on his aneuploidy cancer theory. 33. Unlike single gene disorders, diseases caused by aneuploidy are the result of improper gene dosage, not nonfunctional gene product. 34. Abnormal numbers of chromosomes or chromosome sets, called aneuploidy , may be lethal or may give rise to genetic disorders. 35. Men contaminated with PFCs in whole blood or seminal plasma have spermatozoa with increased levels of DNA fragmentation and chromosomal aneuploidies . 36. These tests can also be performed prenatally to detect aneuploidy in a pregnancy, through either amniocentesis or chorionic villus sampling. 37. Measurement of fetal proteins in maternal serum is a part of standard prenatal screening for fetal aneuploidy and neural tube defects. 38. This, along with errors in meiosis that lead to aneuploidy , can create an environment where autopolyploidy is very likely. 39. Jacobs described her discovery of this first reported human or mammalian chromosome aneuploidy in her 1981 William Allan Memorial Award address. 40. Whole genome duplications are thought to be less detrimental than aneuploidy as the relative dosage of individual genes should be the same.
