Evidence is building that angiotensin II also increases oxidative stress, creating free radicals that in turn stimulate production of AGEs.
32.
The action of AII itself is targeted by angiotensin II receptor antagonists, which directly block angiotensin II AT 1 receptors.
33.
The first drug-like selective and potent angiotensin II, type II receptor agonist with a high oral bioavailability was recently discovered.
34.
Increased levels of circulating angiotensin II result in unopposed stimulation of the AT 2 receptors, which are, in addition, upregulated.
35.
For example, studies in rats and rabbits indicate that angiotensin II-dependent hypertension is abolished by lesioning of the area postrema.
36.
The AT 1 receptor mediates the major cardiovascular effects of angiotensin II . Effects include osmocontrol and extracellular matrix formation.
37.
Alpha II-spectrin gene expression has been shown to be upregulated in cardiac fibroblasts in response to Angiotensin II-induced cardiac remodeling.
38.
The action of AII itself is targeted by angiotensin II receptor antagonists, which directly block angiotensin II AT 1 receptors.
39.
Conversely, when renin levels are low, angiotensin II and aldosterone levels decrease, contracting the extracellular fluid compartment, and decreasing blood pressure.
40.
ACE ( angiotensin converting enzyme ) inhibitors block the enzyme that creates angiotensin II, the most active form of the substance.
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