Receptor agonists and antagonist of angiotensin II receptors that target various parts of the complicated renin-angiotensin system were developed to increase knowledge of the renin-angiotensin system and aid the development of antihypertensive drug candidates.
32.
In the mid-1950s Karl H . Beyer, James M . Sprague, John E . Baer, and Frederick C . Novello of Merck and Co . discovered and developed chlorothiazide, which remains the most widely used antihypertensive drug today.
33.
A hypothesis initially proposed by Wald and Law had recommended a six-drug combination to be taken by patients over age 55 at risk of cardiovascular disease events, which would include three half-dose antihypertensives drugs, aspirin, a statin, and folic acid.
34.
Thus, drugs that have an equal effect on lowering blood pressure may vary in their ability to prevent heart attacks and heart failure, and mechanisms that do not involve blood pressure may be important in determining the therapeutic effects of antihypertensive drugs, Alderman said.
35.
"' Effects of antihypertensive drugs on blood velocity and arterial flow disturbances "'1976, 1980, 1995 : these studies showed that antihypertensive drugs have different effects on blood velocity and arterial flow disturbances, which have implications for how effective they are at fighting the buildup of arterial plaque . ( .)
36.
"' Effects of antihypertensive drugs on blood velocity and arterial flow disturbances "'1976, 1980, 1995 : these studies showed that antihypertensive drugs have different effects on blood velocity and arterial flow disturbances, which have implications for how effective they are at fighting the buildup of arterial plaque . ( .)
37.
But because the drugs are less effective, users do not gain the benefits they would by using other types of antihypertensive drugs, and the reason is unknown, said the scientific team that was led by Dr . Curt D . Furberg of Wake Forest University School of Medicine in Winston-Salem, N . C.
38.
In collaboration with Prof . S�rgio Henrique Ferreira in the last phase of the discovery of a new ACE inhibitor extracted from Bothrops venom, he demonstrated experimentally its efficacy in the reversion of experimental hypertension, thus opening the way for the eventual development of a new antihypertensive drug, captopril ( trademarked Capoten ) by Squibb scientists.
39.
These sales forecasts besides Vioxx are for Zocor, its cholestrol drug, at sales expectations of $ 5.8 billion to $ 6.2 billion; Fosamax, its osteoporosis drug, for $ 1.5 billion to $ 1.7 billion; Hyzaar, its antihypertensive drug, for $ 1.8 billion to $ 2 billion; and Singulair, its asthma controller, for $ 1 billion to $ 1.2 billion.
40.
Studies in this Phase aim to show that the new drug has a useful amount of the desired clinical activity ( e . g ., that an experimental antihypertensive drug reduces blood pressure by a useful amount ), that it can be tolerated when given to humans in the longer term, and to investigate which dose levels might be most suitable for eventual marketing.
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