31. Arachidonic acid does still play a central role in inflammation related to injury and many diseased states.32. Activated I 1-imidazoline receptors trigger the hydrolysis of phosphatidylcholine into second messengers arachidonic acid and downstream eicosanoids. 33. This enzyme catalyses the synthesis of PGE2 from PGH2 ( produced by cyclooxygenase from arachidonic acid ). 34. Like other formamidines amitraz inhibits the synthesis of prostaglandin E2 from arachidonic acid by bovine seminal vesicle microsomes. 35. It is produced by the oxygenation of arachidonic acid by two enzymes : cycloxygenase and thromboxane A2 synthase. 36. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. 37. This channel could accommodate arachidonic acid without much computation, defining the substrate binding details for the lipoxygenase reaction. 38. Cytosolic phospholipase A2-? acts on membrane phospholipids to release arachidonic acid a precursor in the synthesis of eicosanoids. 39. CYP2C9 * 3 ( 42624A > C, rs1057910, Iso359Leu ) encodes an expoxygenase with reduced arachidonic acid metabolizing activity. 40. Arachidonic acid is the major precursor of prostaglandins, leukotrienes, and anandamides that play a vital role in cell signaling.
