31. Along with histidine 57 and aspartic acid 102, this serine residue constitutes the catalytic triad of the active site. 32. Histidne and aspartic acid residues are also a part of the catalytic triad of chlorophyllase as a serine hydrolase. 33. It contains an aspartic acid residue which has been shown to act as a nucleophile in the catalytic mechanism. 34. As a sidenote, AK-III catalyzes the phosphorylation of aspartic acid that is the commitment step in this biosynthetic pathway. 35. A variant of this method, which has not been used commercially, uses unmodified aspartic acid , but produces low yields. 36. The active site contains two Mg 2 + ions that are stabilized by catalytic Aspartic Acids D419 and D547. 37. This specificity allows caspases to be incredibly selective, with a 20, 000-fold preference for aspartic acid over glutamic acid. 38. They are named Caspases due to their specific cysteine protease activity-a cysteine in its active site aspartic acid amino acid. 39. PMN2, a mutant, dominant version of the gene Sup35p, has a glycine to aspartic acid substitution in the second repeat. 40. M10 is a mutated form of Rev and has a single amino acid substitution ( Aspartic acid to Leucine ).
