Interestingly, flavin reductase / biliverdin-IXbeta reductase has also been shown to exhibit ferric reductase activity, with an apparent K ( m ) of 2.5 microM for the ferric iron.
32.
This binding site attaches to biliverdin, and causes its dissociation from heme oxygenase ( HO ) ( which catalyzes reaction of ferric heme-- > biliverdin ), causing the subsequent reduction to bilirubin.
33.
This binding site attaches to biliverdin, and causes its dissociation from heme oxygenase ( HO ) ( which catalyzes reaction of ferric heme-- > biliverdin ), causing the subsequent reduction to bilirubin.
34.
This reaction can occur in virtually every cell; the classic example is the formation of a bruise, which goes through different colors as it gradually heals : red heme to green biliverdin to yellow bilirubin.
35.
A clue might lie in the fact that biliverdin and other porphyrins do not absorb infrared light ( which is a large proportion of solar energy ), thus they may help the eggs from over heating.
36.
Examinations of eggs attributed to " Heyuannia " by Martin Sanders " et al " revealed the eggs had high levels of biliverdin and protoporphyrin, indicating they were a blue-green in color.
37.
Bile pigments such as biliverdin possess significant anti-mutagenic and antioxidant properties and therefore may fulfil a useful physiological function . as well as having beneficial effects in asthma though further research is needed to confirm these results.
38.
BLVRB binds to human heme oxygenase-1 ( hHO-1 ) in conjunction with cytochrome p450 reductase to catalyzes the NADPH-cytochrome P450 reductase-dependent oxidation of heme to biliverdin, CO, and free iron.
39.
False negatives can also be given by poorly stored samples as the bilirubin is photosensitive and undergoes photo oxidation to biliverdin when it is exposed to light, or hydrolysis of the glucuronide can occur producing free bilirubin which is less reactive.
40.
Mechanistically it is a good model for BVR-A ( biliverdin-IXalpha reductase ), a potential pharmacological target for neonatal jaundice, and also a potential target for adjunct therapy to maintain protective levels of biliverdin-IXalpha during organ transplantation.
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