Sex hormone-binding globulin levels were mildly elevated ( 6.0 10.0 nmol / L ), while thyroxine-binding globulin, corticosteroid-binding globulin, and prolactin levels were all normal.
32.
The two N-terminal LNS ( laminin / neurexin / sex hormone-binding globulin-domain ) domains of the protease ( ?-secretase activity ), showing that NG2 can modulate the neuronal glutamatergic system.
33.
It is unclear whether other serpins can adopt this conformer, and whether this conformation has a functional role, but it is speculated that the ?-conformation may be adopted by Thyroxine-binding globulin during thyroxine release.
34.
This is because the large store of pre-formed T 3 and T 4 in the thyroid gland and bound to thyroid binding globulin ( 99 % bound ) has to be depleted before any beneficial clinical effect occurs.
35.
The compound has been found to occupy binding sites of sex hormone-binding globulin ( SHBG ), thereby reducing the ability of SHBG to bind additional steroid hormones such as estrogens and androgens, mostly testosterone and estradiol.
36.
*During pregnancy, iodine requirements are higher as there is an increased demand for thyroid hormones due to decreased levels of free thyroid hormone secondary to elevated circulating levels of thyroid binding globulin in response to increased estrogen levels.
37.
Combined oral contraception decreases total testosterone levels by approximately 0.5 nmol / l, free testosterone by approximately 60 %, and increases the amount of sex hormone binding globulin ( SHBG ) by approximately 100 nmol / l.
38.
In comparison to levothyroxine ( T 4 ), liothyronine has a faster onset of action as well as a shorter biological half-life, which may be due to less plasma protein binding to thyroxine-binding globulin and transthyretin.
39.
Women who have high amounts of androgen and thus an increase tendency for android fat distribution are in the lowest quintiles of levels of sex-hormone-binding globulin and more are at high risks of ill health associated with android fat
40.
It causes a dose-dependent decrease in luteinizing hormone and follicle-stimulating hormone levels, indicating that it has antigonadotropic activity, and dose-dependently increases sex hormone-binding globulin levels, indicating that it has estrogenic activity in the liver.
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