Arguments for the Chagas hypothesis were mainly his nervous signs and symptoms ( caused in Chagas by an imbalance of the autonomic nervous system ), malaise and fatigue, as well as his ultimate cause of death, which seems to have been chronic cardiac failure ( present in ca . 20 % of Chagas patients, with cardiomegaly and ventricular tip aneurysm ) accompanied by lung edema.
32.
"' The most common causes "'of Cardiomegaly are congenital ( patients are born with the condition based on a genetic inheritance ), high blood pressure which can enlarge the left ventricle causing the heart muscle to weaken over time, and coronary artery disease that creates blockages in the heart's blood supply, which can bring on a cardiac infarction ( heart attack ) leading to tissue death which causes other areas of the heart to work harder, increasing the heart size.
33.
Positron emission tomography data show that with KCNE2, 124I uptake by the thyroid is impaired . " Kcne2 " deletion does not impair organification of iodide once it has been taken up by NIS . Pups raised by " Kcne2 "-/-dams are particularly severely affected because rhey receive less milk ( hypothyroidism of the dams impairs milk ejection ), the milk they receive is deficient in T 4, and they themselves cannot adequately transport iodide into the thyroid . " Kcne2 "-/-pups exhibit stunted growth, alopecia, cardiomegaly and reduced cardiac ejection fraction, all of which are alleviated by thyroid hormone supplementation of pups or dams.
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