31. The optimum pH for cathepsin D in vitro is 4.5-5.0. 32. Jones'dissertation research involved the catalytic properties of cathepsin C, a type of protease. 33. The list of proposed cathepsin S substrates includes laminin, fibronectin elastin, osteocalcin and some collagens. 34. For instance, cleavage of laminin-5 by cathepsin S leads to generation of proangiogenic peptides. 35. That the expression of Cathepsin K is characteristic for some cancers and not others has been documented. 36. Cathepsin -D is an aspartic protease that depends critically on protonation of its active site Asp residue.37. Cathepsin D ( an aspartyl protease ) appears to cleave a variety of substrates such as fibronectin and laminin.38. Cathepsin S is expressed by antigen presenting cells including macrophages, B-lymphocytes, dendritic cells and microglia.39. Cathepsin S plays an active role in blood vessels permeability and angiogenesis due to its elastolytic and collagenolytic activities.40. Knock out of cathepsin L in mice exhibited impaired blood flow restoration in ischemic limbs, indicating impaired neovascularization.
