In tests of various benzodiazepine compounds, chlordiazepoxide was found to cause the most profound reduction in the turnover of 5HT ( serotonin ) in rats.
32.
In 1963, approval for use was given to diazepam ( Valium ), a " simplified " version of chlordiazepoxide, primarily to counteract anxiety symptoms.
33.
Chronic use of benzodiazepines, such as chlordiazepoxide, leads to the development of tolerance, with a decrease in number of benzodiazepine binding sites in mouse forebrain.
34.
Thus our article on the drug chlordiazepoxide ( commonly known as Librium ) is better than our benzodiazepine article, which covers the class of drugs to which Librium belongs.
35.
The first benzodiazepine, chlordiazepoxide ( " Librium " ), was synthesized in 1955 by Leo Sternbach while working at Hoffmann La Roche on the development of tranquilizers.
36.
An example in case is Roche, Switzerland for custom manufacturing precursors of the benzodiazepine class of tranquilizers, such as Librium ( chlordiazepoxide HCl ) and Valium ( diazepam ).
37.
The elimination half-life of diazepam and chlordiazepoxide, as well as other long half-life benzodiazepines, is twice as long in the elderly compared to younger individuals.
38.
Chlordiazepoxide ( Librium ), a long-acting benzodiazepine, is gaining attention as an alternative to diazepam in substance abusers dependent on benzodiazepines due to its decreased abuse potential.
39.
More than 1.2 million were taking diazepam or chlordiazepoxide, which are long-acting sedatives and sleeping pills that can make people groggy, forgetful and prone to falls.
40.
The safety profile of clonazepam during pregnancy is less clear than that of other benzodiazepines, and if benzodiazepines are indicated during pregnancy, chlordiazepoxide and diazepam may be a safer choice.
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