Chromosomal aberrations are disruptions in the normal chromosomal content of a cell and are a major cause of genetic conditions in humans, such as Down syndrome, although most aberrations have little to no effect.
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Genetic Toxicologists at IITRI routinely perform bacterial mutagenesis assays ( Ames Tests ), mammalian mutagenesis assays ( mouse lymphoma and other tests ), DNA damage assays ( micronucleus and chromosomal aberration assays ), and cytotoxicity assays.
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Irradiation of male mice during late spermatogenesis can induce damage that persists for at least 7 days in the fertilizing sperm cells, and disruption of maternal DNA double-strand break repair pathways increases sperm cell-derived chromosomal aberrations.
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"He asked, ` Could viruses have something to do with these chromosomal aberrations ? "'said Dr . Eugene O . Major of the National Institute of Neurological Disorders and Stroke, who collaborated with Neel on the work.
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MMA ( III ) and DMA ( III ) were also shown to be directly genotoxic by effectuating scissions in supercoiled ?X174 DNA . Increased arsenic exposure is associated with an increased frequency of chromosomal aberrations, micronuclei and sister-chromatid exchanges.
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Upon examination, MDS-afflicted FA patients will show many clonal variations, appearing either prior or subsequent to the MDS . Furthermore, cells will show chromosomal aberrations, the most frequent being monosomy 7 and partial hematopoietic progenitor cell transplant is an option ).
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A literature review of " in vivo " studies of BPF found that four out of five studies yielded results that BPF is estrogenic, androgenic and thyroidogenic . " In vitro " studies of BPF showed effects of cytotoxicity, cellular dysfunction, DNA damage and chromosomal aberrations.
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The researchers concluded from testing that when metabolically activated, " PAs produce DNA adducts, DNA cross-linking, DNA breaks, sister chromatid exchange, micronuclei, chromosomal aberrations, gene mutations, and chromosome mutations " in vivo " and " in vitro " . " The most common mutation within the genes ares G : C-- > T : A tranversions and tandem base substitution.
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