Test No . 211 is a 21-day chronic toxicity test, at the end of which, the total number of living offspring produced per parent animal alive at the end of the test is assessed, to determine the lowest observed effect concentration of the test substance.
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Toxicity of vitamin A is believed to be associated with the intervention methods used to upgrade vitamin A levels in the body such as food modification, fortification and supplementation, all of which are employed to combat vitamin A deficiency Toxicity is classified into two categories : acute and chronic toxicities.
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In 2006 the United States Environmental Protection Agency ( USEPA ) re-assessed the classification for amitraz to a non-quantifiable Suggestive Evidence of Carcinogenicity descriptor, and in 2013 determined that quantification of risk using a non-linear approach for amitraz will adequately account for all chronic toxicity, including carcinogenicity, that could result from exposure to amitraz and its metabolites.
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