The Fanconi anemia complementation group ( FANC ) currently includes FANCA, FANCB, FANCC, FANCD1 ( also called BRCA2 ), FANCD2, FANCE, FANCF, FANCG, and FANCL . Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair.
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XP has been classified into eight complementation groups, XP-A to XP-G and XP-V . Cells from XP-A to XP-G patients have defects in the process of nucleotide excision repair ( NER ), which eliminates a wide variety of structurally unrelated lesions, including ultraviolet light ( UV )-induced cyclobutane pyrimidine dimers ( CPD ) and ( 6-4 ) photoproducts, as well as certain chemical adducts.
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