Further emphasizing the relationship between the endoplasmic reticulum and cortical granules, during oocyte maturation, endoplasmic reticulum has been observed to either grow or migrate closer toward the region of cortical granules.
32.
Further emphasizing the relationship between the endoplasmic reticulum and cortical granules, during oocyte maturation, endoplasmic reticulum has been observed to either grow or migrate closer toward the region of cortical granules.
33.
While much has been learned about the identity and function of the contents of the cortical granules in the highly accessible sea urchin, little is known about the contents of cortical granules in mammals.
34.
While much has been learned about the identity and function of the contents of the cortical granules in the highly accessible sea urchin, little is known about the contents of cortical granules in mammals.
35.
More specifically, in mice, for example, the ability to undergo cortical granule exocytosis arises some time between metaphase I and metaphase II of meiosis, which is also 5 hours before ovulation occurs.
36.
It should be noted that, upon fertilization, Protein Kinase C has been shown to promote the sperm's acrosomal exocytosis, a process homologous to that of the oocyte's cortical granule exocytosis.
37.
For instance, the formation of the CGFDs may be the oocyte's mechanism for retaining more cortical granules for future use rather than losing them to the polar bodies as the polar bodies extrude from the cell.
38.
Because some cortical granules released are from a region near the meiotic spindles, researchers have also hypothesized that the released cortical granules may modify the oocyte's extracellular matrix so that sperm cannot bind in this region.
39.
Because some cortical granules released are from a region near the meiotic spindles, researchers have also hypothesized that the released cortical granules may modify the oocyte's extracellular matrix so that sperm cannot bind in this region.
40.
Researchers also hypothesize the oocyte releases some cortical granules pre-fertilzation in order to make minor modifications to the oocyte's extracellular matrix so that binding is limited to only sperm capable of binding despite these minor modifications.
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