31. He and Waters experimented on the gas cyclopropane and were the first doctors to use it on human subjects. 32. The small cycloalkanes in particular, cyclopropane have a lower stability due to Baeyer strain and ring strain. 33. 1, 3-Dibromopropane was used in the first cyclopropane synthesis in 1881, known as the Freund reaction. 34. In 1881 he discovered a method for synthesising cyclopropane : he treated 1, 3-dibromopropane with sodium metal. 35. Due to conformational strain in the cyclopropane ring of the norcaradiene the equilibrium lies on the side of the cycloheptatriene. 36. The added chlorine atom assists in the decarboxylation step and likely serves as the leaving group during cyclopropane ring formation. 37. He also helped develop the anesthetic use for the gas cyclopropane , and he was a pioneer in therapeutic nerve blocking. 38. The systematic name of this enzyme class is "'cycloeucalenol lyase ( cyclopropane -decyclizing ) " '. 39. Alpha-mycolic acids comprise at least 70 % of the mycolic acids present in the organism and contain several cyclopropane rings. 40. Some inhaled anaesthetics used for general anesthesia, such as cyclopropane and halothane, may reduce the effect of oxytocin and ergometrine.
