31. Studies compared this combination against artemether / lumefantrine ( Coartem ) and against chlorproguanil / dapsone ( Lapdap ). 32. Topical dapsone is not recommended for use with benzoyl peroxide due to yellow-orange skin discoloration with this combination. 33. Within a few weeks of therapy some patients may develop acute skin lesions described as sulfone syndrome or dapsone dermatitis. 34. Dapsone is not a first-line topical antibiotic due to higher cost and lack of clear superiority over other antibiotics.35. An ethical dilemma then arose as to whether to give the troops dapsone , an untried drug known to be toxic. 36. Currently, a multidrug treatment ( MDT ) is recommended by the World Health Organization, including dapsone , rifampicin and clofazimine. 37. Dapsone has anti-inflammatory and immunomodulatory effects, which are thought to come from the drug's blockade of myeloperoxidase.38. Acedapsone is a derivative of dapsone that has little activity against M . leprae but is converted to an active dapsone metabolite. 39. Acedapsone is a derivative of dapsone that has little activity against M . leprae but is converted to an active dapsone metabolite. 40. Povidone-iodine and anti-fungal drugs like amphotericin-B, Dapsone and silver nitrate have been suggested as possible antiseptics.
