31. It is not clear how the cell determines the locations of " de novo " 32. Sometimes administrative decisions may be reviewed by the courts on a de novo basis. 33. DRM2 is the only enzyme that has been implicated as a " de novo " 34. The agency had 60 days to reply to the " de novo " application. 35. The enzyme ribonucleotide reductase ( RNR ) catalyzes the de novo synthesis of dNDPs. 36. In this album was present an unreleased song by Palma, Quem �s Tu De Novo 37. In 1975 he was already responsible for the tennis school Sociedade Alian�a de Novo Hamburgo. 38. In 2011 Todd Sacktor proposed a model for how de novo protein synthesis modulates plasticity. 39. That so-called de novo system would be eliminated under the Weld, Keating and Harshbarger proposals. 40. It can also be an individual ( de novo or " sporadic " ) mutation.