Complement activation causes a cascade of events leading to : destruction of endothelial cells, platelet degranulation, inflammation, coagulation, fibrin deposition, and hemorrhage.
32.
At least one clinical study suggested nifedipine, one of the dihydropyridines, may reduce mast cell degranulation in patients who exhibit " urticaria pigmentosa ".
33.
Eosinophilic cutaneous conditions encompass a wide variety of diseases that are characterized histologically by the presence of eosinophils in the inflammatory infiltrate, or evidence of eosinophil degranulation.
34.
The degranulation of basophils can be investigated " in vitro " by using flow cytometry and the so-called basophil-activation-test ( BAT ).
35.
"In vitro " studies have found that ANCAs can activate neutrophils, increase their adherence to endothelium, and induce their degranulation that can damage endothelial cells.
36.
At least one clinical study suggested that nifedipine, a calcium channel blocker used to treat high blood pressure, may reduce mast cell degranulation in patients with urticaria pigmentosa.
37.
Nedocromil acts as a mast cell stabilizer, inhibits the degranulation of mast cells, prevents release of histamine and tryptase, so preventing the synthesis of prostaglandins and leukotrienes.
38.
Cromoglicate-based drugs ( sodium cromoglicate, nedocromil ) block a calcium channel essential for mast cell degranulation, stabilizing the cell and preventing release of histamine and related mediators.
39.
Injectable codeine is available for subcutaneous or intramuscular injection only; intravenous injection is contraindicated as this can result in non-immune mast-cell degranulation and resulting anaphylactoid reaction.
40.
The P2X 7 receptor also serves as a pattern recognition receptor for extracellular ATP-mediated apoptotic cell death, regulation of receptor trafficking, mast cell degranulation, and inflammation.
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