Both modifications are catalyzed by the dioxygenase Asp / Asn-beta-hydroxylase, and are unique to EGF domains in eukaryotes.
32.
Hence blocking the oxidation of 3, 4-DHSA by the extradiol dioxygenase enzyme may be useful in the treatment of tuberculosis.
33.
Several hydroxylase enzymes are believed to incorporate an NIH shift in their mechanism, including 4-hydroxyphenylpyruvate dioxygenase and the tetrahydrobiopterin dependent hydroxylases.
34.
Iron is a 2OG oxygenases, the activity of gamma-butyrobetaine dioxygenase can be stimulated by reducing agents such as ascorbate and glutathione.
35.
Alkaptonuria is caused when an enzyme called homogentisic dioxygenase ( HGD ) is faulty so can't break down homogentisic acid ( HGA ).
36.
Meldonium is used for the treatment of angina and myocardial infarction by inhibiting the carnitine biosynthesis pathway via the inhibition of gamma-butyrobetaine dioxygenase.
37.
The enzyme that 2, 4'- dihydroxyacetophenone dioxygenase transforms 2, 4'- dihydroxyacetophenone and O 2 into 4-hydroxybenzoate and formate.
38.
Oxygen is not only a physiological requirement, but serves as a reactant in the hydroxylation of both aliphatic and aromatic hydrocarbons via monooxygenase and dioxygenase enzymes.
39.
Another theory developed more recently ( 2009 ) suggests that a NO dioxygenase activity could also proceed through phenolic nitration via a putative heme-peroxynitrite intermediate.
40.
COX-2 inhibitors down-regulate indoleamine 2, 3-dioxygenase, leading to a reduction in kynurenine levels as well as reducing proinflammatory cytokine activity.
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