Most cases of Alzheimer's disease do not exhibit autosomal-dominant inheritance and are termed sporadic AD, in which environmental and genetic differences may act as risk factors.
32.
Most cases are found to be sporadic, with no family history of the syndrome, although there have been a few cases in families where autosomal dominant inheritance has been reported.
33.
In X-linked dominant inheritance, when the mother alone is the carrier of a mutated, or defective gene associated with a disease or disorder; she herself will have the disorder.
34.
Huntington's disease has autosomal dominant inheritance, meaning that an affected individual typically inherits one copy of the gene with an expanded trinucleotide repeat ( the mutant allele ) from an affected parent.
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The autosomal dominant inheritance model has not been validated, and past research has been affected by the problem of referred samples, which may not reflect broader populations of persons with Tourette's.
36.
Hypotheses that have been proposed include : environmental / external factors; peripheral neural dysfunction; failure of the development of mesodermic vessels in an early embryonic stage; autosomal dominant inheritance with incomplete penetrance and, finally, the theory of Happle.
37.
Platt's position was that hypertension was a simple disease caused by perhaps just one genetic defect, and he presented evidence of its autosomal dominant inheritance and a bimodal distribution of blood pressures, indicating that hypertensives were a distinct subpopulation in humans.
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In medicine, X-linked dominant inheritance indicates that a gene responsible for a genetic disorder is located on the X chromosome, and only one copy of the allele is sufficient to cause the disorder when inherited from a parent who has the disorder.
39.
Autosomal dominant inheritance indicates that the gene responsible for the disorder is located on an autosome ( chromosome 10 is an autosome ), and only one defective copy of the gene is sufficient to cause the disorder, when inherited from a parent who has the disorder.
40.
Over half of the cancers in Li-Fraumeni families had been previously associated with inactivating mutations of the p53 gene, and, in one primary research study, DNA sequencing in samples taken from five Li Fraumeni syndrome families showed autosomal dominant inheritance of a mutated TP53 gene.
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