One phenomenon associated with prazosin is known as the " first dose response ", in which the side effects of the drug specifically orthostatic hypotension, dizziness, and drowsiness are especially pronounced in the first dose.
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Studying dose response, and developing dose response models, is central to determining " safe " and " hazardous " levels and dosages for drugs, potential pollutants, and other substances to which humans or other organisms are exposed.
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For policy making purposes, the commonly accepted model of dose response in radiobiology is the linear no-threshold model ( LNT ), which assumes a strictly linear dependence between the risk of radiation-induced adverse health effects and radiation dose.
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"I think the interesting things are the size of the effect and the dose response, " said Dr . Sheldon Cohen, a psychiatry professor at Carnegie Mellon University in Pittsburgh who was the lead author of the study.
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A five-week combined Phase 1 and 2 open label, forced titration dose response study of 21 healthy adults suggested that the Ambrotose AO dietary supplement was safe and raised serum Oxygen Radical Absorbance Capacity ( ORAC ) by 36.6 %.
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An alternative type of model in toxicology is the linear no-threshold model ( LNT ), while hormesis correspond to the existence of opposite effects at low vs . high dose, which usually gives a U-or inverted U-shaped dose response curve.
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The study, which investigated leukaemia and brain cancer, indicated a linear dose response in the low dose region and had qualitative estimates of risk that were in agreement with the Life Span Study ( Epidemiology data for low-linear energy transfer radiation ).
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In Schild regression, the change in the dose ratio, the ratio of the EC 50 of an agonist alone compared to the EC 50 in the presence of a competitive antagonist as determined on a dose response curve used to determine the affinity of an antagonist for its receptor.
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One interesting result from the Ames test is that the dose response curve using varying concentrations of chemical is almost always linear, However some proposed that organisms can tolerate low level of mutagens due to protective mechanisms such as DNA repair, and threshold may exist for certain chemical mutagens.
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In 2012, a systematic review covering all articles in the literature related to isotretinoin, depression and suicide, as well as articles related to class effect, dose response, and biologic plausibility found that the literature reviewed was consistent with an association of isotretinoin administration and depression and with suicide in a subgroup of vulnerable individuals.
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