31. Estrogens should only be used for the shortest possible time and at the lowest effective dose due to these risks. 32. There is very little difference between an effective dose and a lethal dose of anesthetic in crabeater seals, she said. 33. Just half of fenitrothion's minimally effective dose altered the thyroid structure of a freshwater murrel ( the snakehead fish ). 34. If the active compound has a short half-life, it would require a large amount to maintain a prolonged effective dose . 35. Effective dose is used to estimate stochastic risks for a reference person, which is an average of the population.36. Using much the same concept, Mann and MiniMed are pursuing a pump system for more effective dosing of AIDS drugs. 37. To minimise the risk of physical / psychological dependence, lorazepam is best used only short-term, at the smallest effective dose . 38. The median " effective dose " for these symptoms ranged from nine sessions for overeating to more than 104 for paranoia. 39. The sum of effective doses to all organs and tissues of the body represents the effective dose for the whole body. 40. Nature Made recommends from one to eight pills a day, with two a day the most effective dose for most people.