31. However, inhaled A1AT may not reach the elastin fibers in the lung where elastase injury actually occurs. 32. Elastase -like proteases have a much smaller S1 cleft than either trypsin-or chymotrypsin-like proteases.33. MMP9, along with elastase , appears to be a regulatory factor in neutrophil migration across the basement membrane. 34. SLPI is one of the major defenses against the destruction of pulmonary tissues and epithelial tissues by neutrophil elastase . 35. Gelatinase B, along with elastase , appears to be a regulatory factor in neutrophil migration across the basement membrane. 36. The activity of elastase is increased by human serum albumin, which is the most abundant protein found in chronic wounds. 37. However it was later discovered that it was the only chymotrypsin-like elastase that was not expressed in the pancreas. 38. In humans, neutrophil elastase is encoded by the " ELANE " gene, which resides on chromosome 19. 39. Neutrophil elastase has been shown to interact with Alpha 2-antiplasmin, which belongs to the Serpin family of proteins. 40. The genes encoding this protein, neutrophil elastase 2, and proteinase 3 are in a cluster located at chromosome 19pter.
