31. One study reports that HHeC catalyzed ( R )-epoxide up to 99 % enantiomeric excess. 32. The primary mechanism of the 4-hydroxycoumarin drugs is the inhibition of vitamin K epoxide reductase. 33. The vitamin K epoxide reductase complex subunit 1 ( VKORC1 ) is responsible for the pharmacodynamics of warfarin. 34. When alkene 2 undergoes epoxidation with m-chloroperbenzoic acid ( MCPBA ), epoxide 3 is formed. 35. Human microsomal epoxide hydrolase is coded by EPHX1 gene located on chromosome 1 ( 1q42.12 ). 36. Vitamin K is changed to its active form in the liver by the enzyme Vitamin K epoxide reductase. 37. The intermediate subsequently closes, as controlled by the catalyst structure, to form the epoxide product stereoselectively. 38. Another modification of C-3'with cyclopropane and epoxide moieties were also found to be potent. 39. It also functions to create zeaxanthin, where it catalyses the reduction of two epoxide groups from violaxanthin. 40. In principle, any molecule containing a reactive hydrogen may react with the epoxide groups of the epoxy resin.
