The condition varies from a mild, self-limited rash ( E . multiforme minor ) to a severe, life-threatening form known as "'erythema multiforme major "'( or "'erythema multiforme majus "') that also involves mucous membranes.
32.
Other clinically important side effects with less than 10 % frequency were ventricular arrhythmia, inflammation of parts of the eye ( iridocyclitis ), infusion-related reactions, dizziness, peripheral and sensory neuropathy, peeling skin, erythema multiforme, vitiligo, and psoriasis.
33.
Medications that have traditionally been known to lead to SJS, erythema multiforme, and toxic epidermal necrolysis include sulfonamide antibiotics, penicillin antibiotics, cefixime ( antibiotic ), barbiturates ( sedatives ), lamotrigine, phenytoin ( e . g ., Dilantin ) ( anticonvulsants ) and trimethoprim.
34.
From the date of initial marketing, December 1998, to January 30, 2007, the US Food and Drug Administration received six cases of severe cutaneous adverse reactions associated with modafinil, including erythema multiforme ( EM ), Stevens Johnson syndrome ( SJS ), toxic epidermal necrolysis ( TEN ), and DRESS syndrome, involving adult and pediatric patients.
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