In this form of AML, levels of erythroblasts can reach up to 94.8 % of all nucleated cells in the bone marrow, and the immature forms of the erythroblasts, the proerythroblasts and basophilic erythroblasts, are more commonly found.
32.
Cell number in a colony is important because pro-erythroblast stage is also Epo-responsive ( expresses Epo receptor ), but the proliferative capacity of these cells is not as high, thus yielding a colony with fewer than 8 cells.
33.
One study noted that in control leukemic groups with general AML, immature erythroblasts accounted for 8 % of all erythroid cells, but in a group with pure erythroid leukemia, this number was a minimum of 40 %, and ranged up to 83 %.
34.
Early erythroid progenitors are found at a quite low frequency relative to later stages of erythroid differentiation, such as the pro-erythroblast and the basophilic erythroblast stages which can be detected by flowcytometry directly ex-vivo ( Socolovsky et al . 2001 PMID 11719363 ).
35.
Early erythroid progenitors are found at a quite low frequency relative to later stages of erythroid differentiation, such as the pro-erythroblast and the basophilic erythroblast stages which can be detected by flowcytometry directly ex-vivo ( Socolovsky et al . 2001 PMID 11719363 ).
36.
It is unknown whether EpoR signaling plays a " permissive " ( i . e . induces only survival ) or an " instructive " ( i . e . upregulates erythroid markers to " lock " progenitors to a predetermined differentiation path ) role in early, multipotent progenitors in order to produce sufficient erythroblast numbers.
37.
Furthermore, unlike for the pro-erythroblast and later stages of erythroid development, no truly reliable and unique positive flow-cytometric markers exist, though it is possible to use negative exclusion markers to deplete a cell population of other precursors and differentiated cells by cell sorting, thus greatly enriching it for the CFU-e activity ( Prospective isolation and global gene expression analysis of the erythrocyte colony-forming unit, Terszowski G . et al.
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