31. Another proposed mechanism for release of vesicle contents into extracellular fluid is called kiss-and-run fusion. 32. Doripenem s distribution volume is close to that of extracellular fluid volume in humans ( 18.2 L ). 33. The physiological function of autotaxin is the production of the signalling lipid lysophosphatidic acid ( LPA ) in extracellular fluids . 34. In contrast to extracellular fluid , cytosol has a high concentration of potassium ions and a low concentration of sodium ions. 35. This primarily occurs through maintenance of the extracellular fluid compartment, the size of which depends on the plasma sodium concentration. 36. Lymph is considered to be extracellular fluid until it enters the lymphatic vessels where it is then considered to be lymph. 37. IgG is the main type of antibody found in blood and extracellular fluid allowing it to control infection of body tissues. 38. This increase in osmotic plasma levels causes extracellular fluid volume to increase which triggers receptors in both the brain and heart. 39. Insulin increases the activity of Na / K ATPase, causing increased movement of potassium into cells from the extracellular fluid . 40. Changes in the pH of arterial blood ( and therefore the extracellular fluid ) outside this range result in irreversible cell damage.