31. When iron concentration is low, IRPs bind the ferritin mRNA IRE leading to translation repression. 32. Ferritin that is not combined with iron is called "'apoferritin " '.33. For this reason, low ferritin levels carry more information than those in the normal range. 34. The serum C reactive protein, erythrocyte sedimentation rate, and ferritin level are markedly elevated. 35. Once inside, the cell transfers the iron to ferritin , the internal iron storage molecule. 36. A major function of ferritin is the storage of iron in a soluble and nontoxic state. 37. As ferritin is an acute-phase reactant, it may be elevated in inflammatory states. 38. Wild type ferritin functions as a buffer for iron, sequestering it and controlling its release. 39. Two key players involved in iron transport and storage in the body are ferritin and transferrin. 40. Serum ferritin in excess of 1000 nanograms per millilitre of blood is almost always attributable to haemochromatosis.
