31. This is evidence that the " kaiABC " gene cluster is not necessary for growth. 32. The avermectin initial aglycon is further modified by other enzymes in the avermectin biosynthetic gene cluster . 33. This gene is highly conserved in vertebrates which is upstream from the alpha globin gene cluster . 34. Exchangeable apolipoproteins ( apoA, apoC and apoE ) have the same gene cluster on chromosome 11. 35. The figure below shows the proposed biosynthesis of psymberin based on analysis of the gene clusters . 36. This enzyme is a member of a metabolic gene cluster along with two other cytochrome P450s. 37. Some lasso peptide biosynthetic gene clusters also require an additional protein of unknown function for biosynthesis. 38. The expansion of a gene cluster is the duplication of genes that leads to larger gene families. 39. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. 40. Because these duplicates are false positives in the search for gene clusters they have to be excluded.