31. In 2014, Orphan Drug Status was granted by the FDA for glioblastoma multiforme. 32. Glioblastomas are very agressive, Cravens notes.33. The diagnosis : grade IV glioblastoma multiforme. 34. Both the protein and transcript are overexpressed in glioblastoma cells, promoting their haptotactic migration. 35. De Mae was diagnosed with glioblastoma , an aggressive form of brain cancer in July 2004. 36. In glioblastoma a more or less specific mutation of EGFR, called EGFRvIII is often observed. 37. Glioblastomas are considered a subset of astrocytomas a particularly damaging, invasive, and undifferentiated type.38. In addition, microarray data indicates that CARKD is up-regulated in Glioblastoma multiforme tumors. 39. In glioblastoma three proteins collaborate similarly. 40. Another positive prognostic marker for glioblastoma patients is mutation of the " IDH1 " gene,
