31. Plasmepsins I and II cleave hemoglobin between residues Phenylalanine 33 and Leucine 34 of ?-globin subunit. 32. Usually there are four genes that code for alpha globin and two genes that code for beta globin. 33. Usually there are four genes that code for alpha globin and two genes that code for beta globin . 34. The CoTC core is highly conserved in the 3'UTR of other primate beta-globin genes. 35. Both of these globins contain an virginal prosthetic group for binding oxygen and they contain many similar structural characteristics. 36. GATA1 was first described as a red blood cell lineage transcription factor that activates the beta-globin gene. 37. Hb H usually occurs in some alpha thalassemia and is composed of four beta globin ( protein ) chains. 38. Some mutations in the globin chain are associated with the hemoglobinopathies, such as sickle-cell disease and thalassemia. 39. Thalassemias, in contrast, usually result in underproduction of normal globin proteins, often through mutations in regulatory genes. 40. Bacteria have all three types of globins , while archaea lack flavohaemoglobins, and eukaryotes lack globin-coupled sensors.
