Another chemical extracted from the species was an acidic polysaccharide ( made up of mostly mannose, glucose, glucuronic acid and xylose ) which showed anticoagulant properties.
32.
It is possible to exhaust the bodies supply of glucuronic acid by combining multiple drugs / substances whose metabolism and excretion are primarily or entirely dependent on glucuronidation.
33.
This enzyme is located on the endoplasmic reticulum and catalyse the conjugation of a wide variety of lipophilic aglycon substrates with glucuronic acid, using uridine diphosphate glucuronic acid.
34.
This enzyme is located on the endoplasmic reticulum and catalyse the conjugation of a wide variety of lipophilic aglycon substrates with glucuronic acid, using uridine diphosphate glucuronic acid.
35.
In the most common scenario, the hydroxyls of the 4 and 6 positions of the N-acetyl-galactosamine are sulfated, with some chains having the 2 position of glucuronic acid.
36.
It is composed of pentasaccharide repeat units, comprising glucose, mannose, and glucuronic acid in the precipitated from a growth medium with isopropyl alcohol, dried, and ground into a fine powder.
37.
Increased GCA activity results in a decrease of the concentration and metabolic half-life of glucuronic acid substrates, causing the plasma levels of glucuronidated drugs to fall below their therapeutic threshold.
38.
Neonates are deficient in this conjugating system, making them particularly vulnerable to drugs such as chloramphenicol, which is inactivated by the addition of glucuronic acid, resulting in gray baby syndrome.
39.
The substances resulting from glucuronidation are known as glucuronides ( or glucuronosides ) and are typically much more water-soluble than the non-glucuronic acid-containing substances from which they were originally synthesised.
40.
It is localized to the golgi membrane, and catalyzes the transfer of sulfate to the C4 hydroxyl of beta-1, 4-linked N-acetylgalactosamine ( GalNAc ) flanked by glucuronic acid residue in chondroitin.
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