31. During puberty increased gonadotropin secretion stimulates a rise in sex steroids creation from the testes. 32. At low concentration, estrogen inhibits gonadotropins , but high concentration of estrogen stimulates them. 33. However, it does not suppress gonadotropin secretion or inhibit ovulation at typical clinical dosages. 34. Usually associated with markedly elevated levels of Beta-human chorionic gonadotropins ( HCG ). 35. Also during the 1980s, doctors began using the gonadotropins without IVF and in stronger doses. 36. Human chorionic gonadotropin also plays a role in cellular differentiation / proliferation and may activate apoptosis. 37. In a 1985 case, a California woman gave birth to septuplets after taking the gonadotropin Pergonal. 38. Insulin also has stimulatory effects on gonadotropin -releasing hormone from the hypothalamus, thus favoring fertility. 39. A low dose of human chorionic gonadotropin ( HCG ) may be injected after completed ovarian stimulation. 40. Gonadotropin -releasing hormone ( GnRH ) is secreted from the hypothalamus by GnRH-expressing neurons.