Seegmiller's laboratory team at NIH went on to discover that some men have partial HGPRT deficiency that causes high levels of uric acid in the blood and leads to the development of gouty arthritis and the formation of uric acid stones in the urinary tract.
32.
The later historian Pelayo of Oviedo, who continued Sampiro's chronicle down to his own age, replaced this laudatory section with an attack on the king, bequeathing to historiography the nickname by which Vermudo II is always known : " the Gouty " ( " el Gotoso " ).
33.
In a review of the performance, The New Yorker said : " Professor Tigar went way past ham ( he went whole hog ) into eloquence in the part of Andrew Hamilton, the aged, gouty Philadelphia attorney who persuades the jury to disregard the corrupt instructions of the judge handpicked by Governor Cosby and instead to find Zenger not guilty ."
34.
X-ray diffraction studies on the hydrogen urate ion in crystals of ammonium hydrogen urate, formed " in vivo " as gouty deposits, reveal the keto oxygen in the 2 position of a tautomer of the purine structure exists as a hydroxyl group and the two flanking nitrogen atoms at the 1 and 3 positions share the ionic charge in the six-membered pi-resonance-stabilized ring.
35.
Many of Davidson's political views were expressed in a series of columns published in the " Fulton Democrat ", in which Davidson assumed the persona of Uncle Zeb, a " rheumatic, choleric, gouty old bachelor . " During the Civil War, Davidson espoused the anti-war Peace Democrat or Copperhead point of view in his newspaper editorials, arguing, for example, that military officers desired to prolong the war because they were earning high salaries.
36.
The specific diseases and conditions where it used include gouty arthritis, skin tophi, kidney stones idiopathic gout; uric acid lithiasis; acute uric acid nephropathy; neoplastic disease and myeloproliferative disease with high cell turnover rates, in which high urate levels occur either spontaneously, or after cytotoxic therapy; certain enzyme disorders which lead to overproduction of urate, for example : hypoxanthine-guanine phosphoribosyl transferase, including Lesch-Nyhan syndrome; glucose-6-phosphatase including glycogen storage disease; phosphoribosyl pyrophosphate synthetase, phosphoribosyl pyrophosphate amidotransferase; adenine phosphoribosyl transferase.
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