Several recent colon cancer screening guidelines have recommended replacing any older low-sensitivity, guaiac-based fecal occult blood testing ( gFOBT ) with either newer high-sensitivity guaiac-based fecal occult blood testing ( gFOBT ) or fecal immunochemical testing ( FIT ), which tests for globin rather than the heme detected by the guaiac method.
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Several recent colon cancer screening guidelines have recommended replacing any older low-sensitivity, guaiac-based fecal occult blood testing ( gFOBT ) with either newer high-sensitivity guaiac-based fecal occult blood testing ( gFOBT ) or fecal immunochemical testing ( FIT ), which tests for globin rather than the heme detected by the guaiac method.
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FIT screening is more effective in terms of health outcomes and cost compared with guaiac FOBT . According to the guidelines of the American College of Gastroenterology, " Annual fecal immunochemical testing is the preferred colorectal cancer detection test . " A FIT test detects globin levels in feces at or above 50 nanograms per mL, the established cutoff by the World Health Organization for Colorectal Cancer Screening.
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