31. The histone methyltransferases are specific to either lysine or arginine. 32. Many corepressors can recruit histone deacetylase ( HDAC ) enzymes to promoters. 33. The nucleosome octamer includes two copies of each histone H4. 34. This protein acetylates both histone and non-histone proteins. 35. This protein acetylates both histone and non-histone proteins. 36. Histone acetylation / deacetylation alters chromatin structure and affects transcription.37. However, IRF2 also functions as a transcriptional activator of histone H4. 38. This protein also mediates transcriptional repression through interaction with histone deacetylase 1. 39. The encoded protein can phosphorylate myelin basic protein and histone in vitro. 40. Other histone modifications have similar or opposite effects on transcription.