It does not have analgesic effects in its own right, but prevents the development of hyperalgesia, and also shows antidepressant effects in animal studies.
32.
It has been used to research the involvement of the 5-HT 7 receptor in as yet poorly understood processes such as allodynia and hyperalgesia.
33.
Identifying the development of hyperalgesia is of great clinical importance since patients receiving opioids to relieve pain may paradoxically experience more pain as a result of treatment.
34.
Ablation of ?-opioid-expressing neurons in the RVM with a dermorphin-saporin conjugate eliminated the allodynia and hyperalgesia caused by a nerve injury.
35.
Recent evidence for generalized increased pain sensitivity or hyperalgesia in CTTH strongly suggests that pain processing in the central nervous system is abnormal in this primary headache disorder.
36.
He found that among the cytokines, interleukin 1b mediates the endogenous release of prostaglandins and IL-8 is responsible for the development of the sympathetic hyperalgesia.
37.
This abnormal central sensitization cycle results in increased pain ( hyperalgesia ) and pain responses from previously non-noxious stimuli evoke a pain response ( allodynia ).
38.
Injection of the CCK-saporin conjugate also reversed allodynia and hyperalgesia in a nerve injury model, producing the same results as the dermorphin-saporin conjugate.
39.
The suggestion that chronic pain patients who are diagnosed as experiencing opioid-induced hyperalgesia ought to be completely withdrawn from opioid therapy has also been met with criticism.
40.
Various tolerance to opioid analgesic drugs, and in the emergence of side-effects such as hyperalgesia and allodynia that can become a problem following extended use of opioid drugs.
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