Most congenital hyperinsulinism is caused by different mechanisms than excessive proliferation of beta cells in a fetal pattern and the term fell into disfavor after it was recognized in the late 1980s that the characteristic tissue features were sometimes seen in pancreatic tissue from normal infants and even adults, and is not consistently associated with hyperinsulinemic hypoglycemia.
32.
Overweight and obese children also had significantly higher levels of hypertension ( control 3.4 %, overweight 7.3 %, obese 19 % ), impaired glucose tolerance ( control : normal, overweight 1.3 %, obese 5.3 % ) and hyperinsulinism ( control 8 %, overweight 19.5 %, obese 38.9 % ).
33.
Dr Lutz was to find that his low carbohydrate diet was effective with both childhood obesity and with hyperinsulinism-a hormonal pathway to both common obesity and, through exhaustion of supply, to morbus Crohn and ulcerative colitis to osteoarthritis; he showed low carbohydrate nutrition could lower cholesterol levels, normalise high and low levels of blood iron and calcium and ease many problems of reproduction.
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