31. "' Vorozole "'is an imidazole based competitive inhibitor of the aromatase enzyme. 32. As a result, imidazole engineering has been suggested as a means to specifically inhibit NO dioxygenases. 33. But the imidazole and pyridine lone pairs also look good for accounting for some of those pKas. 34. Also, calculations show that the C4 hydrogen is less acidic than the C2 hydrogen of imidazole . 35. The difference between the imidazoles and the triazoles involves the mechanism of inhibition of the cytochrome P450 enzyme. 36. Like other imidazole antifungals, sertaconazole blocks the synthesis of ergosterol by inhibiting the 14?-demethylase enzyme. 37. The distal imidazole is not bonded to the iron but is available to interact with the substrate O 2. 38. Glyoxal is a valuable building block in organic synthesis, especially in the synthesis of heterocycles such as imidazoles . 39. It also suggests that the use of an imidazole -imidazolium conversion controls access to the allosteric B site. 40. 1-Methylimidazole is also the precursor for the synthesis of the methylimidazole monomer of pyrrole-imidazole polyamides.
