Some of the mesoderm derivatives include the muscle ( smooth, cardiac and skeletal ), the muscles of the tongue ( occipital somites ), the pharyngeal arches muscle ( muscles of mastication, muscles of facial expressions ), connective tissue, dermis and subcutaneous layer of the skin, bone and cartilage, dura mater, endothelium of blood vessels, red blood cells, white blood cells, microglia and Kupffer cells, the kidneys and the adrenal cortex.
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Ellett, J . D ., C . Atkinson, Z . P . Evans, Z . Amani, E . Balish, M . G . Schmidt, R . G . Schnellmann and K . D . Chavin ( 2011 ) . " Toll-like receptor 4 knockout mice are protected from endothelial overactivation in the absence of Kupffer cells after total hepatic ischemia / reperfusion . " Liver Transpl 17 ( 9 ) : 1089-1098.
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While the most likely cellular targets and executors of the CB 2 receptor-mediated effects of endocannabinoids or synthetic agonists are the immune and immune-derived cells ( e . g . leukocytes, various populations of T and B lymphocytes, monocytes / macrophages, dendritic cells, mast cells, microglia in the brain, Kupffer cells in the liver, etc . ), the number of other potential cellular targets is expanding, now including endothelial and smooth muscle cells, fibroblasts of various origins, cardiomyocytes, and certain neuronal elements of the peripheral or central nervous systems.
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