31. You can't get into Phase 1 if you have brain metastases ." 32. It has been found that angiogenesis inhibitors would therefore prevent the growth of metastases . 33. Distant metastases to the lung are most common. 34. Breast cancer may invade directly through local spread, and through lymph node metastases . 35. Unknown primary tumors and rarely, urinary or respiratory tract malignancies cause umbilical metastases . 36. Sister Mary Joseph nodule is associated with multiple peritoneal metastases and a poor prognosis. 37. In renal cancer, sometimes such solitary metastases can be very effectively treated surgically. 38. In a Warsaw hospital he was diagnosed with dangerous metastases of an advanced cancer. 39. Rib fractures are common in breast, prostate and other cancers with rib metastases . 40. Researchers have detected elevated levels of mir-522 expression in colorectal cancer metastases .