Gopinath's early researches were on the juvenile mitral stenosis, a disease affecting the mitral valve making it shrink, its clinicopathological features and the disease management.
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If the tumor grows inside the heart, it can block blood flow through the mitral valve and cause symptoms of mitral stenosis or mitral regurgitation.
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It has also been used to diagnose severity of left ventricular failure and mitral stenosis, given that elevated pulmonary capillary wedge pressure strongly suggests left ventricular output.
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If pulmonary hypertension secondary to mitral stenosis is severe, the P 2 ( pulmonic ) component of the second heart sound ( S 2 ) will become loud.
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He checked himself into a hospital in New York City where a doctor diagnosed him with mitral stenosis, a condition which caused his heart to beat in odd rhythms.
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He was also the first to give a comprehensive description of mitral stenosis, as well as other types of heart disease and centrum semiovale, which is sometimes referred to as " Vieussens'centrum ".
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The pressure gradient can be abnormally low in the presence of mitral stenosis, heart failure, co-existent aortic regurgitation and also ischaemic heart disease ( disease related to decreased blood supply and oxygen causing ischemia ).
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Since the normal left ventricular diastolic pressures is about 5 mmHg, a pressure gradient across the mitral valve of 20 mmHg due to severe mitral stenosis will cause a left atrial pressure of about 25 mmHg.
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The most common historical cause is a dilated left atrium due to mitral stenosis, but other causes, including pulmonary hypertension, thoracic aortic aneurysms, an enlarged pulmonary artery and aberrant subclavian artery syndrome have been reported compressing the nerve.
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Mitral stenosis typically progresses slowly ( over decades ) from the initial signs of mitral stenosis to NYHA functional class II symptoms to the development of atrial fibrillation to the development of NYHA functional class III or IV symptoms.
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