;Reducing body myopathy ( RBM ) : A rare disorder causing progressive muscular weakness characterized by aggresome-like inclusions in the myofibrils.
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The term " myofibril " should not be confused with " myofiber ", which is a simply another name for a muscle cell.
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Labels : A : Motor Neuron Axon B : Axon Terminal C : Synaptic Cleft D : Muscle Cell E : Part of a Myofibril
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The myofibrils are composed of actin and myosin filaments, repeated in units called sarcomeres, which are the basic functional units of the muscle fiber.
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Tropomodulin basically acts to stabilize the F-actin present in the myofibrils present in muscle sarcomeres, which are structures characterized by their great stability.
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It contains mostly myofibrils ( which are composed of sarcomeres ), but its contents are otherwise comparable to those of the cytoplasm of other cells.
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Reading around in the following Skeletal muscle Sarcomere Myofibril Satellite cells Muscle contraction Muscle hypertrophy Muscle atrophy will help clarify what we know of the picture to date.
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This is true up to a point, however beyond this there is a loss of contractile ability due to loss of connection between myofibrils; see figure.
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A decreased availability of 250HD leads to mishandling of cellular calcium transport to the sarcoplasmic reticulum and mitochondria, and is associated with reduced actomyosin content of myofibrils.
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The Purkinje fibers are further specialized to rapidly conduct impulses ( numerous fast voltage-gated sodium channels and mitochondria, fewer myofibrils than the surrounding muscle tissue ).
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