31. Metofluthrin is neurotoxic , and is not meant to be applied directly to human skin. 32. The fruit bodies of " H . nidulans " are neurotoxic if ingested. 33. "Apomastus schlingeri " have a venom that is highly neurotoxic in effect. 34. Methylphenidate may protect neurons from the neurotoxic effects of Parkinson's disease and methamphetamine abuse. 35. It is neurotoxic in large doses. 36. It has very potent neurotoxic venom which it uses to prey on eels and small fish. 37. All small animals have neurotoxic venom. 38. Unlike amphetamine, methamphetamine is directly neurotoxic to dopamine neurons in both lab animals and humans. 39. All three of these actions result in increased levels of glutamate activity that could be neurotoxic . 40. COX-2 is upregulated in many neurotoxic disorders and is associated with increased ROS production.