The process of neural tube transformation into structures that will eventually develop into the central nervous system is known as neurulation, the success of which is dependent on the presence of folate within the body.
32.
Suppression of P4 signaling following withdrawal of progesterone, or treatment with the progesterone receptor antagonist RU-486 ( mifepristone ), inhibits the differentiation of hESC colonies into embryoid bodies ( blastulation ) or rosettes ( neurulation ).
33.
Prior to neurulation, during the migration of epiblastic endoderm cells towards the hypoblastic endoderm, the notochordal process opens into an arch termed the "'notochordal plate "'and attaches overlying neuroepithelium of the neural plate.
34.
This process begins in the human approximately 21 days after conception, and is completed by 28 days . Thus, a woman may not even be aware of her pregnancy by the time the process of neurulation is complete, potentially causing severe consequences in the development of the fetus.
35.
Callebaut and Van Nueten were able to determine that the differentiation of Koller'sickle cells to sickle endoblast is irreversible, and that the sickle endoblast induces early neurulation; they did this by implanting Koller's sickle tissue into different parts of unincubated chicken blastoderms and observing the effects.
36.
During the blastula and gastrula stages, " Wnt " as well as FGF pathways will induce the antero-posterior axis formation, regulate the precise placement of the primitive streak ( gastrulation and mesoderm formation ) as well as the process of neurulation ( central nervous system development ).
37.
In primary neurulation, the layer of ectoderm divides into three sets of cells : the neural tube ( future brain and spinal cord ), epidermis ( skin ), and neural crest cells ( connects epidermis and neural tube and will migrate to make neurons, glia, and skin cell pigmentation ).
38.
An in vitro model of early human embryogenesis ( human embryonic stem cells ( hESCs ) ) has demonstrated that hCG promotes cell proliferation via the LH / hCG receptor ( LHCGR ) . hCG signaling upregulates the expression of steroidogenic acute regulatory protein ( StAR )-mediated cholesterol transport and the synthesis of progesterone in hESC . The production of progesterone at this time induces embryroid body ( akin to blastulation ) and rosette ( akin to neurulation ) formation in vitro.
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