When the team tested nitrogen mustard in a man whose lymphoma cancer had become resistant to radiation, the patient responded as well as the mouse.
32.
"' Chlornaphazine "', a derivative of 2-naphthylamine, is a nitrogen mustard that was developed in the 1950s for the treatment of polycythemia and Hodgkin's disease.
33.
While investigating chemical warfare agents in 1942, Goodman's team noted that the blood of soldiers exposed to nitrogen mustard had abnormally low levels of white cells.
34.
Nitrogen mustards are not related to the mustard plant or its pungent essence, allyl isothiocyanate; the name comes from the pungent smell of chemical weapons preparations.
35.
This is because carboxycyclophosphamide cannot undergo ?-elimination ( the carboxylate acts as an electron-donating group, forbidding the transformation ), preventing nitrogen mustard activation and subsequent alkylation.
36.
The top molecule is bound reversibly, but the lower one is bound covalently as it has reacted with an amino acid residue through its nitrogen mustard group.
37.
China's large oil reserves and petrochemical industry probably were adequate to manufacture blister ( Lewisite, sulfur, and nitrogen mustards ) in large quantities, perhaps by the mid-1950s.
38.
Estramustine phosphate is also an estradiol ester, but with a nitrogen mustard moiety attached, and is used as an alkylating antineoplastic agent in the treatment of prostate cancer.
39.
Three classes of chemicals are monitored under this Convention, with sulfur and nitrogen mustard grouped in Schedule 1, as substances with no use other than in chemical warfare.
40.
Next, in collaboration with a thoracic surgeon, Gustaf Lindskog, they injected a related agent, mustine ( the prototype nitrogen mustard anticancer chemotherapeutic ), into a patient with non-Hodgkin's lymphoma.
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