This is because the FFAA mutation keeps FEN1 from interacting with PCNA ( proliferating cell nuclear antigen ), consequently not allowing it to complete its purpose during Okazaki fragment maturation.
32.
After DNA repair factors replace the ribonucleotides of the primer with deoxynucleotides, a single gap remains in the sugar-phosphate backbone between each Okazaki fragment in the lagging duplex.
33.
Importantly, this priming action occurs at replication initiation at origins to begin leading-strand synthesis and also at the 5'end of each Okazaki fragment on the lagging strand.
34.
Pol ? is responsible for the initiation of DNA replication at origins of replication ( on both the leading and lagging strands ) and during synthesis of Okazaki fragments on the lagging strand.
35.
While the leading strand can use a single RNA primer to extend the 5'terminus of the replicating DNA strand, multiple RNA primers are responsible for lagging strand synthesis, creating Okazaki fragments.
36.
The leading strand is primed once, and the lagging strand is primed approximately every 1000 ( + /-200 ) base pairs ( one primer for each Okazaki fragment on the lagging strand ).
37.
The leading strand is synthesized continuously and in juxtapose to the leading strand; the lagging strand is replicated through short fragments of polynucleotide ( Okazaki fragments ) in a 5'to 3'direction.
38.
Lagging strand synthesis takes place after the helicase has unwound a sufficient quantity of the lagging strand, and this " sufficient quantity of the lagging strand " is polymerised in discrete nucleotide chains called Okazaki fragments.
39.
DNA Pol III uses one set of its core subunits to synthesize the leading strand continuously, while the other set of core subunits cycles from one Okazaki fragment to the next on the looped lagging strand.
40.
However recombination can be restored to near normal levels by a deletion in " rad2 ", a gene that encodes an endonuclease involved in Okazaki fragment processing ( Farah et al ., 2005 ).
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