31. The logic gates are made of the E6 Deoxyribozymes ( or DNAzyme ) which react to specific oligonucleotide input. 32. This ncRNA was originally identified in E . coli using high-density oligonucleotide probe arrays ( microarray ). 33. Placement of a TINA molecule in the oligonucleotide is capable of improving the analytical sensitivity of the probe hybridization. 34. Klenow polymerase then catalyses elongation of the mRNA s 3 end, using the DNA oligonucleotide as a template. 35. The combination of immunostimulation with the technology of siRNA ( gene silencing ) opened new opportunities for oligonucleotide therapeutics. 36. "' Afovirsen "'is an oligonucleotide capable of antisense interactions with mRNA of human papillomavirus. 37. Modifying the 5'- 3'Tm of the oligonucleotide , which leads to a lower target affinity. 38. Antisense oligonucleotides, siRNA, and other oligonucleotide and nucleic acid based biotherapeutics can be quantified with hybridization assays. 39. The hybridization probe for primer extension is a synthesized oligonucleotide , whereas S1 mapping requires isolation of a DNA fragment. 40. One of the cases of successful applications of customized oligonucleotide chips include detection of beta-thalassemia mutation in patients.
